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Post-doctoral Position

ABG-82270 Emploi Niveau d'expérience indifférent
09/01/2019 CDD 24 Mois > 35 et < 45 K€ brut annuel
University of Kentucky
Lexington - Etats-Unis d'Amérique
Biologie
obesity, blood pressure, kidney, adipose tissues, cardiovascular disease
Autre fonction

Employeur

 

‘’The epidemic of obesity, currently affecting more than 30% of the population in the United States, has contributed to a dramatic rise in the prevalence of hypertension. Anti-hypertensive drugs are commonly used to treat hypertension but evidence indicates that the mortality rate is fully 42% higher in the hypertensive than in the normotensive population, underscoring the severity of the problem. According to recent findings released from the National Heart Lung and Blood Institute (NHLBI), a blood pressure below 120 mmHg decreases the risk of cardiovascular diseases in adults. In this context, the identification of novel molecules/receptors involved in obesity and hypertension will allow us to better understand the link between obesity and hypertension and find novel therapeutic treatments for these highly prevalent diseases. Adipose tissue is an important source of elevated circulating concentrations of AngII, which contributes to hypertension in obese mice. While examining the component of the renin angiotensin system in adipocytes, I found that adipose tissue expresses prorenin receptor (PRR). Previous studies focused on the functional role of PRR brain and kidney have involved PRR in the regulation of blood pressure and in the activation of an intracellular pathway involved in hypertrophy, fibrosis, contractility and apoptosis. Recent studies have also suggested a role of PRR in Wnt signaling and V-ATPase activity. My research program focuses on the determination of the role of PRR in fat mass growth, the mechanism by which PRR is involved in obesity and its role in the regulation of blood pressure.’’

Poste et missions

Postdoctoral position:

The laboratory of Dr. Yiannikouris of the Department of Pharmacology and Nutritional Sciences at the University of Kentucky seeks a postdoctoral student interested in hypertension associated with obesity. A full time postdoctoral position is available starting around April-July 2019 for 2 years. The lab has recently secured NIH funding to study the role of the prorenin receptor and its soluble form in hypertension associated with obesity. The candidate must be proficient in the field of renal, vascular research or obesity. The candidate should have practical experience in using laboratory techniques of molecular biology (PCR, RT-PCR, western blot). Expertise in the implantation of radiotelemetry transmitters or in renal physiology and/or genetic would be a plus. The successful candidate is expected to be highly motivated, have scientific independence, excellent scientific writing and oral communication skills, and international peer-reviewed publications. Interested applicants should submit an application package that includes a cover letter, CV, and contact information for three references to Dr. Frederique Yiannikouris. Application review will begin immediately.

Mobilité géographique :

Internationale

Profil

The candidate must be proficient in the field of renal, vascular research or obesity. The candidate should have practical experience in using laboratory techniques of molecular biology (PCR, RT-PCR, western blot). Expertise in the implantation of radiotelemetry transmitters or in renal physiology and/or genetic would be a plus.

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