Impact of endocrine disruptors on thymus and the regulation of T cell differentiation

It is hypothesized that endocrine disrupting molecules that bind to AhR will affect thymic architecture, i.e., thymic epithelial cell homeostasis, thus altering thymic structure. Because thymic functionality is intimately linked to structure, we further hypothesize that disruption of normal thymus development will have long-term consequences on adult health. Given that the thymus is a highly conserved primary immune organ, it is assumed that adaptive immunity will be compromised in both model species BALB/c mouse and the European seabass, Dicentrarchus labrax). Particularly, we will decipher the signaling pathways by which endocrine disruptors modulate thymus development and identify the developmental stages that are the most sensitive and vulnerable as well as the most the concentrations that are most effective. Furthermore, it will be investigated whether the changes in the thymic architecture lead to decreased immunocompetence of fish and, therefore, increased disease susceptibility.

The successful candidate will work at UMR I02 SEBIO, University Le Havre Normandy, France and at the UMRS 974 SU-INSERM, Paris, France.

We are looking for a highly motivated candidate with good theoretical and technical skills in molecular, cell biology and toxicology. The candidate must demonstrate skills in laboratory work (seriousness, rigor, personal involvement), as well as intellectual curiosity, a critical mind. Mobility is required as the candidate will carry out experiments in two institutions

. The candidate should hold a Master 2 or equivalent diploma. French speaking is not required.