Analysis of turn-rich bioactive peptide properties through an approach combining solution and solid-state NMR and theoretical calculations
ABG-125462 | Thesis topic | |
2024-08-19 | Public funding alone (i.e. government, region, European, international organization research grant) |
- Chemistry
- Biochemistry
Topic description
Bioactive peptides have emerged as a promising class of drugs in the field of pharmacology, due to their specificity and their capacity to selectively target distinct biological processes. Their use as therapeutic agents has become widespread, with various administration routes (dry or wet forms). An important question is how the peptide structure may be affected by the nature of the formulation.
The main objective of this project is to evaluate the impact of the physical state of bioactive peptides, especially those rich in turns in drug preformulation stages. To this end, we plan to develop an approach combining liquid and solid-state NMR, as well as theoretical calculations. We will first investigate the complementarity of liquid and solid-state NMR in beta-turn characterization using model peptides. Then we will apply the developed methodologies to bioactive peptides of interest.
Starting date
Funding category
Funding further details
Presentation of host institution and host laboratory
The COBRA (Organic and Bioorganic Chemistry: Reactivity and Analysis) laboratory is a joint research unit (UMR-6014) associating the University of Rouen Normandy, INSA Rouen Normandy, and CNRS. The laboratory is primarily located in the IRCOF building (Institute of Research in Fine Organic Chemistry) in Mont-Saint-Aignan.
The overall scientific objective of the COBRA laboratory is to develop innovative methods in organic synthesis, analytical chemistry, and molecular modeling and apply them to various sub-domains of the discipline (bioorganic chemistry, pharmaceutical chemistry, eco-friendly chemistry, materials chemistry) relying on a high-performing research team in analysis.
Website :
PhD title
Country where you obtained your PhD
Institution awarding doctoral degree
Graduate school
Candidate's profile
The applicant should have a Master Degree with a speciality in Analytical Chemistry, Physical Chemistry or Structural Biology. He/She must also have taken courses on NMR spectroscopy. Crystallisation, peptide/protein NMR or molecular modeling knowledge would be an asset. Fluency in English (both oral and written) is mandatory.
Vous avez déjà un compte ?
Nouvel utilisateur ?
Get ABG’s monthly newsletters including news, job offers, grants & fellowships and a selection of relevant events…
Discover our members
PhDOOC
ANRT
TotalEnergies
Groupe AFNOR - Association française de normalisation
Aérocentre, Pôle d'excellence régional
Ifremer
Tecknowmetrix
Laboratoire National de Métrologie et d'Essais - LNE
Généthon
Nokia Bell Labs France
Institut de Radioprotection et de Sureté Nucléaire - IRSN - Siège
ONERA - The French Aerospace Lab
ADEME
SUEZ
MabDesign
MabDesign
CASDEN
CESI
Institut Sup'biotech de Paris
-
JobPermanentRef. ABG123642Laboratoire des Courses Hippiques (GIE LCH)- Ile-de-France - France
Chargé(e) de Recherche et Innovation (H/F) / Senior Scientist Research & Innovation (M/F)
Chemistry - BiochemistryConfirmed -
JobPermanentRef. ABG125568Cours GalienBordeaux Grenoble Saint Etienne - Grand Est - France
Résponsable pédagogique études médicales
Biology - Health, human and veterinary medicineAny -
Thesis topicRef. ABG125548Centre de Recherche en CardioVasculaire et Nutrition (C2VN) - INSERM 1263 - INRAE 1260 - Aix-Marseille universitéMarseille - Provence-Alpes-Côte d'Azur - France
Mechanisms involving neutrophils in Venous Thrombosis / Etude des mécanismes impliquant les neutrophiles dans la thrombose veineuse
Biology