Hydrogels composites pour l'administration de plusieurs médicaments // Composite hydrogels for dual drug delivery

A controlled drug delivery system (DDS) facilitates the sustained release of a biologically active agent to decrease the number of administrations, to allow for low doses and to protect the drug from degradation.
The development of innovative delivery systems is essential for the treatment of many diseases as biochemical cues in the form of drugs can provide a decisive role in the therapeutic outcome.

Protein drugs now play a significant role in almost every field of medicine. Moreover, combination therapy with drugs having different therapeutic effects has shown great promise for the treatment of various diseases as it may exhibit exceptional synergy with reduced side effects compared to monotherapy; it may also be an asset to overcome the challenge of drug resistance.

Combination therapy with a protein and a small molecule drug (SMD) is particularly useful in view of their different, synergistically operating action mechanisms.

However, achieving co-delivery is challenging because of the often distinct physical and
chemical properties of both drug classes, hindering their integration into a single carrier.
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Début de la thèse : 01/10/2024
WEB : https://www.cemef.minesparis.psl.eu/wp-content/uploads/2024/06/PhD-position-CEMEF_Buwalda.pdf

https://www.minesparis.psl.eu/

Connaissance de la science des matériaux, des polymères et des applications biomédicales maîtrise de l'anglais très motivé(e)
Knowledge of materials science, polymers as well as biomedical applications fluent in English highly motivated & pro-active MSc thesis completed