Airway inflammation in Cystic Fibrosis and CFTR correction

Our group located at “Institut Necker Enfants Malades” (INEM), Paris, is seeking for a post doctoral fellow interested by airway inflammation. 

INEM is located in the Necker Hospital campus which provides an exceptional scientific and academic environment. Administered jointly by INSERM, CNRS and the Université de Paris, INEM benefits from close contacts with clinicians and state-of-the-art technological platforms in one of France’s foremost research centered universities.

Our research aims to understand the inflammation pathways remodeled by highly efficient CFTR modulation including the protease anti-protease balance, oxidative stress and interaction with innate immune cells. This will be based on a multi-omic approach of patient primary airway cultures under different experimental conditions and study of sputum samples collected longitudinally in a pediatric cohort. 

The ideal candidate will have expertise in standard molecular biology techniques and mammalian cell culture; experience in inflammation is desirable but not essential.
Highly motivated candidates with a Ph.D. or M.D./Ph.D. are welcome to apply. Applicants should possess strong laboratory, analytical, interpersonal and communication skills. 

Our research aims to understand the inflammation pathways remodeled by highly efficient CFTR modulation including the protease anti-protease balance, oxidative stress and interaction with innate immune cells. This will be based on a multi-omic approach of patient primary airway cultures under different experimental conditions and study of sputum samples collected longitudinally in a pediatric cohort.