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Thesis topic Biotechnology

Rational development of small molecule splicing modifiers.

INSERM U1212-CNRS UMR 5320 Thesis

, Nouvelle Aquitaine , France

Specific mRNA splicing correction using small molecules is an emerging field of drug discovery which has already provided innovative therapeutic applications in the context of inherited diseases. In the context of Spinal Muscular Atrophy (Naryshkin NA ...

Scientific expertises : Biochemistry - Biotechnology - Chemistry

Keywords : RNA splicing correction, small molecule, RNA therapeutics

Ref. ABG-129163

2025-03-05

Thesis topic

Other public funding

Revolutionizing High-Precision Non-Invasive Brain Treatments with Advanced Numerical Modeling

ICube (UMR 7357) Thesis

, Grand Est , France

Transcranial Focused Ultrasound (tFUS) is a groundbreaking technology that can treat neurological conditions like Parkinson’s disease, epilepsy, and even enable targeted drug delivery—without invasive surgery. However, accurately focusing ...

Scientific expertises : Biotechnology - Digital - Health, human and veterinary medicine

Keywords : transcranial ultrasound, treatment targeting, numerical optimization

Ref. ABG-129115

2025-03-04

Thesis topic

Public/private mixed funding

Sujet de thèse : Stress Minéral et Santé – Imagerie et histologie des nanoparticules de calcium-phosphate en physiopathologie

SAINBIOSE, INSERM U1059, Thesis

SAINT ETIENNE , Auvergne-Rhône-Alpes , France

Contexte scientifique : Le vieillissement humain s’accompagne de perturbations du métabolisme hydrominéral, conduisant à la perte de masse osseuse, à des calcifications pathologiques des tissus durs (micropétro ...

Scientific expertises : Health, human and veterinary medicine - Biotechnology - Engineering sciences

Keywords : Imaging, calcium-phosphate, nanoparticules, matrix vesicles, lighsheet imaging

Ref. ABG-128661

2025-02-15

Thesis topic

Public funding alone (i.e. government, region, European, international organization research grant)

Mucines et protection des épithéliums sécrétoires

Infinte U1286 Thesis

Lille , Les Hauts de France , France

L’hydrogel de mucus est la première défense innée qui recouvre les épithéliums sécrétoires. Ce fluide biologique complexe est essentiel pour la flore résidente et piège les agents pa ...

Scientific expertises : Biology - Biotechnology - Health, human and veterinary medicine

Keywords : mucus, mucines, santé féminine, infection, imagerie

Ref. ABG-128104

2025-01-24

Thesis topic

Public funding alone (i.e. government, region, European, international organization research grant)

Bacterial Reservoir Computer

Jean-Loup Faulon Thesis

, Ile-de-France , France

In contrast to traditional bottom-up approaches that build biological devices for computation within organisms [1-3], this PhD project proposes a novel top-down strategy. The goal is to leverage bacterial strains in a reservoir computing (RC) framewor ...

Scientific expertises : Biotechnology

Keywords : Systems Biology , Machine Learning, Reservoir Computing, Synthetic Biology , Genome-Scale Metabolic Models, Microbiology

Ref. ABG-128046

2025-01-21

Thesis topic

Other public funding

PhD grant: Molecular modeling of DNA damage in the cell nucleus

Universite de Lille Thesis

Lille , Les Hauts de France , France

The DNASTRIX project aims at investigating and quantifying how nuclear mechanics can be altered by forces issued from the cellular environment, and what are some key genomic implications of such mechanical processes, potentially involved in many human ...

Scientific expertises : Physics - Biotechnology - Electronics

Keywords : computer simulation; DNA-protein interactions; molecular dynamics; nuclear mechanics

Ref. ABG-126146

2024-10-06

Thesis topic

Public funding alone (i.e. government, region, European, international organization research grant)